Pesquisa | Portal de Pesquisa da BVS

1.

Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia.

Ahmad, Zahid; Banerjee, Poulabi; Hamon, Sara; Chan, Kuo-Chen; Bouzelmat, Aurelie; Sasiela, William J; Pordy, Robert; Mellis, Scott; Dansky, Hayes; Gipe, Daniel A; Dunbar, Richard L.

Circulation ; 140(6): 470-486, 2019 08 06.

Artigo em Inglês | MEDLINE | ID: mdl-31242752

2.

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

Dewey, Frederick E; Gusarova, Viktoria; Dunbar, Richard L; O'Dushlaine, Colm; Schurmann, Claudia; Gottesman, Omri; McCarthy, Shane; Van Hout, Cristopher V; Bruse, Shannon; Dansky, Hayes M; Leader, Joseph B; Murray, Michael F; Ritchie, Marylyn D; Kirchner, H Lester; Habegger, Lukas; Lopez, Alex; Penn, John; Zhao, An; Shao, Weiping; Stahl, Neil; Murphy, Andrew J; Hamon, Sara; Bouzelmat, Aurelie; Zhang, Rick; Shumel, Brad; Pordy, Robert; Gipe, Daniel; Herman, Gary A; Sheu, Wayne H H; Lee, I-Te; Liang, Kae-Woei; Guo, Xiuqing; Rotter, Jerome I; Chen, Yii-Der I; Kraus, William E; Shah, Svati H; Damrauer, Scott; Small, Aeron; Rader, Daniel J; Wulff, Anders Berg; Nordestgaard, Børge G; Tybjærg-Hansen, Anne; van den Hoek, Anita M; Princen, Hans M G; Ledbetter, David H; Carey, David J; Overton, John D; Reid, Jeffrey G; Sasiela, William J; Banerjee, Poulabi.

N Engl J Med ; 377(3): 211-221, 2017 07 20.

Artigo em Inglês | MEDLINE | ID: mdl-28538136

3.

Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.

McLaren, David G; Previs, Stephen F; Phair, Robert D; Stout, Steven J; Xie, Dan; Chen, Ying; Salituro, Gino M; Xu, Suoyu S; Castro-Perez, Jose M; Opiteck, Gregory J; Akinsanya, Karen O; Cleary, Michele A; Dansky, Hayes M; Johns, Douglas G; Roddy, Thomas P.

J Lipid Res ; 57(3): 398-409, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26658238

4.

Measurement of LDL-C after treatment with the CETP inhibitor anacetrapib.

Davidson, Michael; Liu, Sherry Xueyu; Barter, Philip; Brinton, Eliot A; Cannon, Christopher P; Gotto, Antonio M; Leary, Elizabeth T; Shah, Sukrut; Stepanavage, Michael; Mitchel, Yale; Dansky, Hayes M.

J Lipid Res ; 54(2): 467-72, 2013 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-23172660

5.

Safety of anacetrapib in patients with or at high risk for coronary heart disease.

Cannon, Christopher P; Shah, Sukrut; Dansky, Hayes M; Davidson, Michael; Brinton, Eliot A; Gotto, Antonio M; Stepanavage, Michael; Liu, Sherry Xueyu; Gibbons, Patrice; Ashraf, Tanya B; Zafarino, Jennifer; Mitchel, Yale; Barter, Philip.

N Engl J Med ; 363(25): 2406-15, 2010 Dec 16.

Artigo em Inglês | MEDLINE | ID: mdl-21082868

6.

Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.

Altarejos, Judith Y; Pangilinan, Jeffrey; Podgrabinska, Simona; Akinci, Baris; Foss-Freitas, Maria; Neidert, Adam H; Ray, Yonaton; Zheng, Wenjun; Kim, Steven; Kamat, Vishal; Huang, Meilin; Min, Soo; Mastaitis, Jason; Dominguez-Gutierrez, Giselle; Kim, Jee-Hae; Stevis, Panayiotis; Huang, Tammy; Zambrowicz, Brian; Olson, William C; Godin, Stephen; Bradley, Elizabeth; Gewitz, Andrew D; Baker, Mark; Hench, Rita; Davenport, Matthew S; Chenevert, Thomas L; DiPaola, Frank; Yancopoulos, George D; Murphy, Andrew J; Herman, Gary A; Musser, Bret J; Dansky, Hayes; Harp, Joyce; Gromada, Jesper; Sleeman, Mark W; Oral, Elif A; Olenchock, Benjamin A.

Sci Transl Med ; 15(723): eadd4897, 2023 11 22.

Artigo em Inglês | MEDLINE | ID: mdl-37992152

7.

Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib.

Krauss, Ronald M; Wojnooski, Kathleen; Orr, Joseph; Geaney, J Casey; Pinto, Cathy Anne; Liu, Yang; Wagner, John A; Luk, Julie Mabalot; Johnson-Levonas, Amy O; Anderson, Matt S; Dansky, Hayes M.

J Lipid Res ; 53(3): 540-547, 2012 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-22180633

8.

Efficacy and safety after cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib (MK-0859) in patients with primary hypercholesterolemia or mixed hyperlipidemia.

Dansky, Hayes M; Bloomfield, Daniel; Gibbons, Patrice; Liu, Sherry; Sisk, Christine McCrary; Tribble, Diane; McKenney, James M; Littlejohn, Thomas W; Mitchel, Yale.

Am Heart J ; 162(4): 708-16, 2011 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-21982664

9.

Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors.

Shan, Jian; Nguyen, Thomas B; Totary-Jain, Hana; Dansky, Hayes; Marx, Steven O; Marks, Andrew R.

Proc Natl Acad Sci U S A ; 105(48): 19006-11, 2008 Dec 02.

Artigo em Inglês | MEDLINE | ID: mdl-19020099

10.

Novel strategy using F1-congenic mice for validation of QTLs: studies at the proximal chromosome 10 atherosclerosis susceptibility locus.

Teupser, Daniel; Wolfrum, Susanne; Tan, Marietta; Persky, Adam D; Dansky, Hayes M; Breslow, Jan L.

Arterioscler Thromb Vasc Biol ; 29(5): 678-83, 2009 May.

Artigo em Inglês | MEDLINE | ID: mdl-19251590

11.

Found in translation.

Shaywitz, David; Dansky, Hayes.

Nat Biotechnol ; 25(5): 601, 2007 May.

Artigo em Inglês | MEDLINE | ID: mdl-17483843

12.

Symptoms and Dietary Impact in Hypertriglyceridemia-Associated Pancreatitis: Development and Content Validity of Two New Measures.

Burbridge, Claire; Randall, Jason A; Sanchez, Robert J; Dansky, Hayes; Symonds, Tara; Girman, Cynthia J; Strayer, Joshua A; Selk, Karen L; Whitcomb, David C; Kershaw, Erin E.

Pharmacoecon Open ; 4(1): 191-201, 2020 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-31250380

13.

Design of the DEFINE trial: determining the EFficacy and tolerability of CETP INhibition with AnacEtrapib.

Cannon, Christopher P; Dansky, Hayes M; Davidson, Michael; Gotto, Antonio M; Brinton, Eliot A; Gould, A Lawrence; Stepanavage, Michael; Liu, Sherry Xueyu; Shah, Sukrut; Rubino, Joseph; Gibbons, Patrice; Hermanowski-Vosatka, Anne; Binkowitz, Bruce; Mitchel, Yale; Barter, Philip.

Am Heart J ; 158(4): 513-519.e3, 2009 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-19781408

14.

Recipes for creating animal models of diabetic cardiovascular disease.

Hsueh, Willa; Abel, E Dale; Breslow, Jan L; Maeda, Nobuyo; Davis, Richard C; Fisher, Edward A; Dansky, Hayes; McClain, Donald A; McIndoe, Richard; Wassef, Momtaz K; Rabadán-Diehl, Cristina; Goldberg, Ira J.

Circ Res ; 100(10): 1415-27, 2007 May 25.

Artigo em Inglês | MEDLINE | ID: mdl-17525381

15.

Found in translation.

Shaywitz, David; Dansky, Hayes.

Nature ; 446(7136): 700, 2007 Apr 05.

Artigo em Inglês | MEDLINE | ID: mdl-17421074

16.

Increased neointimal formation after surgical vein grafting in a murine model of type 2 diabetes.

Salzberg, Sacha P; Filsoufi, Farzan; Anyanwu, Anelechi; von Harbou, Kai; Karlof, Eva; Carpentier, Alain; Dansky, Hayes M; Adams, David H.

Circulation ; 114(1 Suppl): I302-7, 2006 Jul 04.

Artigo em Inglês | MEDLINE | ID: mdl-16820590

17.

Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice.

Molnar, Judit; Yu, Shuiqing; Mzhavia, Nino; Pau, Clara; Chereshnev, Igor; Dansky, Hayes M.

Circ Res ; 96(11): 1178-84, 2005 Jun 10.

Artigo em Inglês | MEDLINE | ID: mdl-15879311

18.

Diabetic vascular disease: an experimental objective.

Goldberg, Ira J; Dansky, Hayes M.

Arterioscler Thromb Vasc Biol ; 26(8): 1693-701, 2006 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-16763160

19.

A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse.

Dansky, Hayes M; Shu, Pei; Donavan, M; Montagno, Jill; Nagle, Deborah L; Smutko, John S; Roy, Natalie; Whiteing, S; Barrios, Judith; McBride, T J; Smith, Jonathan D; Duyk, Geoffrey; Breslow, Jan L; Moore, Karen J.

Genetics ; 160(4): 1599-608, 2002 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-11973313

20.

Differential effects of angiotensin II on atherogenesis at the aortic sinus and descending aorta of apolipoprotein-E-deficient mice.

Zhou, Ying; Chen, Rong; Catanzaro, Sarah E; Hu, Lufei; Dansky, Hayes M; Catanzaro, Daniel F.

Am J Hypertens ; 18(4 Pt 1): 486-92, 2005 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-15831357

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Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia.

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.

Measurement of LDL-C after treatment with the CETP inhibitor anacetrapib.

Safety of anacetrapib in patients with or at high risk for coronary heart disease.

Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.

Changes in lipoprotein subfraction concentration and composition in healthy individuals treated with the CETP inhibitor anacetrapib.

Efficacy and safety after cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib (MK-0859) in patients with primary hypercholesterolemia or mixed hyperlipidemia.

Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors.

Novel strategy using F1-congenic mice for validation of QTLs: studies at the proximal chromosome 10 atherosclerosis susceptibility locus.

Found in translation.

Symptoms and Dietary Impact in Hypertriglyceridemia-Associated Pancreatitis: Development and Content Validity of Two New Measures.

Design of the DEFINE trial: determining the EFficacy and tolerability of CETP INhibition with AnacEtrapib.

Recipes for creating animal models of diabetic cardiovascular disease.

Found in translation.

Increased neointimal formation after surgical vein grafting in a murine model of type 2 diabetes.

Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice.

Diabetic vascular disease: an experimental objective.

A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse.

Differential effects of angiotensin II on atherogenesis at the aortic sinus and descending aorta of apolipoprotein-E-deficient mice.